Drug Uses
Carisoprodol is a muscle relaxant used to relieve the pain and stiffness of muscle spasms and discomfort due to strain and sprain.
How Taken
Carisoprodol is taken orally. The usual adult dosage of Carisoprodol is one 350 mg tablet, three times daily and at bedtime. Usage in patients under age 12 is not recommended. It is recommended that you take Carisoprodol with food, or with milk, to minimize the likelihood that you will suffer an upset stomach as a result of taking the medication.
Warnings/Precautions
Do not take Carisoprodol if you have acute intermittent porphyria.
Before taking Carisoprodol, tell your doctor if you have kidney or liver disease. You may need a lower dose or special monitoring during your therapy.
It is not known whether Carisoprodol will harm an unborn baby. Do not take Carisoprodol without first talking to your doctor if you are pregnant.
It is also not known whether Carisoprodol passes into breast milk. Do not take Carisoprodol without first talking to your doctor if you are breast-feeding a baby.
Carisoprodol is not approved for use in children younger than 12 years of age.
Missed Dose
If you miss a Carisoprodol dose, take it as soon as remembered if it is within an hour or so. If you do not remember until later, skip the missed dose and resume your usual dosing schedule. Do not 'double-up' the Carisoprodol dose to catch up.
Possible Side Effects
Carisoprodol may cause dizziness, vertigo, ataxia, tremor, agitation, irritability, headache, depressive reactions, syncope, and insomnia. Allergic or idiosyncratic reactions occasionally develop. They are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug. Skin rash, erythema multiforme, pruritus, eosinophilia, and fixed drug eruption with cross reaction to meprobamate have been reported with Carisoprodol. Severe reactions have been manifested by asthmatic episodes, fever, weakness, dizziness, angioneurotic edema, smarting eyes, hypotension, and anaphylactoid shock.
Storage
Store at controlled room temperature 15°-30°C (59°-86°F). Dispense in a tight container.
Overdose
Seek emergency medical attention. Symptoms of a Carisoprodol overdose include low blood pressure (weakness, fainting, confusion), decreased breathing, and unconsciousness.
More Information
Use caution when driving, operating machinery, or performing other hazardous activities. Carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Carisoprodol.
Disclaimer
This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.
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Muscle Relaxant Flexeril 5 mg as effective alone as with Ibuprofen
Data Suggests Taken Alone As Effective As When Taken In Combination With Ibuprofen - Large scale community-based study shows NSAID offers no additional benefit to muscle relaxant in treatment of acute pain and muscle spasm of the back or neck
More is not necessarily better when it comes to treating acute muscle pain and spasm of the back or neck, suggest results from the first community-based trial to evaluate the benefits of adding a non-steroidal anti inflammatory (NSAID) to treatment with a commonly prescribed muscle relaxant. According to the study, the muscle relaxant FLEXERIL 5 mg (cyclobenzaprine HCl), taken three times a day, is as effective alone as when taken in combination with ibuprofen at over-the-counter (OTC) or prescription doses.
More than 770 adult back and neck pain and muscle spasm sufferers at multiple community-based sites throughout the United States completed the randomized, multi-center, open-label one-week study, which compared thrice-daily treatment with FLEXERIL 5 mg alone or in combination with ibuprofen at over-the-counter (1,200 mg/day) or prescription doses (2,400 mg/day). Researchers shared results of the trial today at the 2004 Scientific Assembly of the American College of Emergency Physicians. A final report, including full data on all endpoints, will be completed soon.
"In clinical practice, acute muscle pain with spasm is often treated with an non-steroidal anti-inflammatory drug (NSAID) alone or in combination with a muscle relaxant," explained Martin Childers, D.O., Ph.D., associate professor, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Missouri-Columbia. :The data from this study indicates that the addition of ibuprofen offers no further pain relief compared to taking FLEXERIL 5 mg alone."
About the Study
Men and women between 18 and 65 years of age with acute muscle pain with spasm of the neck or back of up to 14 days participated in the seven-day study conducted by more than 100 physicians. Patients self-reported pain intensity and muscle spasm intensity at baseline and after three and seven days of randomized treatment of FLEXERIL 5 mg three-times-a-day alone or in combination therapy with over-the-counter ibuprofen 400 mg three times a day (tid) or prescription dose ibuprofen 800 mg tid.
Results showed that all three treatments had statistically significant improvements for both spasm and pain from baseline after three and seven days of therapy. Additionally, the changes from baseline were significantly greater after one week of therapy than after three days for all three treatments for spasm and pain. This treatment duration finding was expected and consistent with previous studies. There were no statistically significant differences among the groups.
The types of adverse events observed in this study were consistent with the known safety profiles of these medications.
About FLEXERIL 5 mg
FLEXERIL 5 mg should be used for relief of painful muscle spasm along with rest and physical therapy. It should only be used for short periods of time, usually two-three weeks. FLEXERIL 5 mg is a prescription medicine and should not be taken by patients who have had a recent heart attack or have heart disease. It should not be used by people with an overactive thyroid or who are currently or have recently used MAOIs. Use of FLEXERIL 5 mg with MAOIs can result in serious health complications.
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