Drug Uses

Clarinex is an antihistamine used to relieve the symptoms of hay fever (seasonal allergic rhinitis). Clarinex contains a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.

How Taken

Clarinex comes in tablets to take by mouth. It can be taken with or without food and is usually taken once daily. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Clarinex exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Warnings/Precautions

Before taking Clarinex, tell your doctor if you have ever had an allergic reaction to an antihistamine; kidney disease; or liver disease. You may not be able to take Clarinex, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Clarinex is in the FDA pregnancy category C. This means that it is not known whether Clarinex will be harmful to an unborn baby. Do not take Clarinex without first talking to your doctor if you are pregnant or could become pregnant during treatment. Clarinex passes into breast milk and may affect a nursing infant. Do not take Clarinex without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you miss a dose take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

Possible Side Effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Clarinex. More common side effects may include: dry mouth, fatigue, sleepiness, sore throat. Less common side effects may include: dizziness, dry throat, flu-like symptoms, muscle pain, nausea. Rare side effects may include: acute allergic reaction, hives, itching, rapid heartbeat, rash, shortness of breath, swelling.

Storage

Store at room temperature. Protect from heat. Keep this medication in the container it came in, tightly closed, and out of reach of children.

Overdose

Little is known about the effects of a Clarinex overdose. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately. Symptoms of Clarinex overdose may include: rapid heartbeat, sleepiness.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Although unlikely, Clarinex may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Q: Do you ship Clarinex Internationally?
A: Sorry we ship only within the U.S, we cannot ship Internationally at this time.


Using Pitrakinra to inhibit interleukins-4 and -13 in the lungs may significantly reduce asthma symptoms, according to an article in the medical journal The Lancet, this week's issue.
The authors explain that doctors and scientists have believed for over twenty years that cytokines, such as interleukin-4 or interleukin-13 play a vital role in the onset and development of clinical asthma. However, there has been no scientific evidence that this might be so.
Dr Malinda Longphre, Aerovance Inc, Berkeley, California, USA and team carried out two separate Phase II clinical trials, where patients received Pitrakinra. In the first study 12 volunteers received 25mg of Pitrakinra by subcutaneous injection once per day. The patients in the second study were given either 60mg of Pitrakinra twice a day by nebulization, and another 16 received a placebo. In both trials the volunteers inhaled allergens before and four weeks after treatment - the allergens are designed to induce an asthma attack, the patient during an asthma attack of this type finds it harder to expel air.
The primary endpoint for the first trial was a maximum percentage drop in forced expiratory volume (FEV1)** in one second over 4-10 hours after receiving the allergen. In the second study the primary endpoint was average percentage fall in FEV1 over 4-10 hours after being given the allergen. If smaller falls in FEV1 during the asthma attack for the Pitrakinra group compared to the placebo group were detected, this would indicate that the allergic response had been reduced by Pitrakinra.
In the first study, say the researchers, the maximum percentage fall in FEV1 was 17.1% in the Pitrakinra and 23.1% in the placebo groups - a comparable difference of 26%. In the second study the average percentage drop in FEV1 was 4.4% in the Pitrakinra versus 15.9% in the placebo group - in other words, it was over three and a half times less in the Pitrakinra group.
"The effects of pitrakinra on late phase asthmatic response are promising when compared with similar studies with other successful anti-inflammatory asthma therapies...whether the effect is due to inhibition of interleukin-13 alone, or both interleukin-13 an interleukin-4, is not yet known. Future studies of this drug, as well as molecules that specifically inhibit interleukin-13, in asthmatic individuals of all levels of severity over longer periods of time are clearly warranted," the writers conclude.

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