Drug Uses

Denavir is a topical antiviral medication used for recurrent cold sores (herpes labialis) on the lips and face in otherwise healthy adult patients. Denavir topical may also be used for purposes other than those listed in this medication guide.

How Taken

Apply Denavir every two hours during waking hours for four days to your cold sore with your finger or a cotton swab. Wash hands with soap and water to prevent it from coming into contact with your eyes or other areas; to prevent irritation and to prevent spread of the herpes virus.

Warnings/Precautions

Denavir is a topical cream that is applied externally on the lips and face. Do not apply Denavir on mucous membranes inside the mouth, nose, genital or rectal areas. Denavir topical is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not use Denavir topical during pregnancy without first talking to your doctor. It is not known whether Denavir topical passes into breast milk. Do not use Denavir topical if you are breast-feeding a baby without first talking to your doctor.

Missed Dose

Use the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and use only your next regularly scheduled dose.

Possible Side Effects

Serious side effects have not been reported with the use of Denavir topical. Other less serious side effects may be more likely to occur. Continue to use Denavir topical and talk to your doctor if you experience: headache; local numbness or tingling where the cream is applied; changes in taste; rash; irritation at the application site. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store at controlled room temperature, 20°-25°C (68°-77°) away from moisture and heat.

Overdose

An overdose of Denavir topical is unlikely to threaten life. If an excessive amount of the cream has been used, or if the cream has been ingested, contact a poison control left or an emergency room for advice.

More Information

Do not use other topical medications to treat the same area at them same time as Denavir topical, unless otherwise directed by your doctor. No other medicines have been reported to interact with Denavir topical. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications during treatment with Denavir topical.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Genital herpes is a highly contagious viral condition caused by the herpes simplex virus (HSV). It principally infects the skin and mucous membranes of the genitals and rectum, but can also appear in areas such as the mouth. It is transmitted primarily through physical and sexual contact. During birth, the presence of herpes simplex virus on the genitalia or in the birth canal is a threat to the infant. Infection in the newborn infant can lead to herpetic meningitis, herpetic viremia (herpes virus particles present in the blood) and chronic skin infection
The symptoms of herpes simplex virus usually occur a week after infection, but sometimes take longer to appear. Initially, the skin becomes reddened and multiple small blisters filled with a clear, straw-coloured fluid appear. Prior to the presence of blisters, the infected individual may also experience increased skin sensitivity, tingling, burning or pain at the site where blisters will appear. Later, the blisters burst leaving shallow, painful ulcers which eventually scab and heal over a period of 7 to 14 days.
The outbreak may be accompanied by other symptoms such as:
# swelling and tenderness of the lymph nodes in the groin area.
# in women, vaginal discharge and painful urination.
# in men, a possibility of painful urination if the lesion is near the opening of the urethra.
# fever.
In most cases, a description of the condition and the appearance of the blisters will be enough to make a diagnosis. The GP may also advise referral to a specialist genitourinary medicine (GUM) clinic for confirmation of the diagnosis.
There is no cure for the herpes simplex virus; once infected, patients will remain a carrier for the rest of their lives. Some remedies, however, can reduce the duration of the eruption. In addition, by being more aware of the initial symptoms of recurrence (skin sensitivity and tingling), timely treatment with medication such as aciclovir (Zovirax tablets/suspension) will often abort the outbreak of blisters.
The best way to prevent recurrence is to avoid direct contact with an open lesion. People with herpes simplex virus should avoid sexual contact when active lesions are present.
Although the symptoms of genital herpes may not be present, it is important for those infected to inform their partner that they have the disease. This will encourage both parties to use barrier protection (condoms) to prevent the spread of the illness. Using condoms and not sharing towels are good ways of reducing the chance of infection in the first place.
For more information, read the factsheet on Herpes genitals.

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