Drug Uses

The antidepressant Lexapro is a member of the family of medications known as selective serotonin reuptake inhibitors (SSRIs). Lexapro offer advantages in the treatment of depression and generalized anxiety disorder.

How Taken

Lexapro comes as a tablet and a liquid taken it orally. It is usually taken once daily and may be taken with or without food. Take Lexapro exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take Lexapro even if you feel well. Do not stop taking Lexapro without talking to your doctor. This drug must be taken regularly for a few weeks before its full effect is felt.

Warnings/Precautions

Before taking Lexapro, tell your doctor if you have liver disease, have kidney disease, suffer from seizures, or suffer from mania or have suicidal thoughts. You may not be able to take Lexapro, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Lexapro should not be taken during treatment with citalopram (Celexa). Also, if you have had an allergic reaction to citalopram (Celexa), you may also have an allergic reaction to Lexapro. Do not take Lexapro without first talking to your doctor if you have had an allergic reaction to either medication in the past. Lexapro is in the FDA pregnancy category C. This means that it is not known whether Lexapro it will be harmful to an unborn baby. Do not take Lexapro without first talking to your doctor if you are pregnant or could become pregnant during treatment. Lexapro passes into breast milk and may affect a nursing infant. Do not take Lexapro without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Lexapro and call your doctor immediately or seek emergency medical treatment:
-an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
-an irregular heartbeat or pulse;
-low blood pressure (dizziness, weakness);
-high blood pressure (severe headache, blurred vision); or
-chills or fever. If you experience any of the following less serious side effects, continue taking Lexapro and talk to your doctor:
-headache, tremor, nervousness, or anxiety;
-nausea, diarrhea, dry mouth, or changes in appetite or weight;
-sleepiness or insomnia; or
-decreased sex drive, impotence, or difficulty having an orgasm.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store Lexapro at room temperature away from moisture and heat.

Overdose

Seek emergency medical attention. Symptoms of a Lexapro overdose include nausea, vomiting, tremor, drowsiness, dizziness, sweating, and a fast heartbeat.

More Information

Do not take Lexapro if you: You have a known sensitivity or allergy to any component of Lexapro.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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A team of researchers from the University of Texas at Austin, led by Kereshmeh Taravosh-Lahn, conducted an animal study in juvenile and adult golden hamsters. The researchers split the hamsters into three groups: adult hamsters receiving either high or low doses of fluoxetine (Prozac), adolescent hamsters receiving high or low doses of fluoxetine, and hamsters receiving placebo. A high dose consisted of 20 mg per kilo of body weight, while a low dose was 10 mg per kilo.
After administering the drugs, the researchers placed a smaller, same-sex hamster into the cage of each experimental animal, and filmed any fights or displays of aggressive behavior. The researchers found that the adolescent hamsters on a low dose of Prozac were far more aggressive than those on high doses of the drug.
The high-dose hamsters initiated 65 percent fewer attacks than the placebo group, while the low-dose hamsters initiated 40 percent more fights. Adult hamsters on both high and low doses of Prozac initiated fewer fights than the placebo group, the researchers found.
Taravosh-Lahn said the difference in aggression between the high- and low-dose hamsters could be because fluoxetine binds serotonin -- a mood-altering brain chemical -- to different receptors in the brain, depending on the dose. The researchers speculate that low doses of the drug may bind to aggression-inducing receptors, while higher doses more readily bind to aggression-inhibiting receptors. Mature animals also have fewer aggression-inducing inhibitors for the drugs to bind to, compared to adolescent animals.
"We underestimate the difference between the juvenile brain and the adult brain," said Taravosh-Lahn. "It seems there needs to be more research on the effects of antidepressants on kids."
Earlier studies have linked use of antidepressant drugs -- specifically SSRIs (selective serotonin reuptake inhibitors) -- to violent and aggressive behavior in children. A high-profile case involving Pzifer's Zoloft SSRI is that of Christopher Pittman, who at the age of 12 shot and killed his grandparents, then set their house on fire. Pittman's attorneys argued that the Zoloft he was taking at the time of the killings caused him to become violent, but a jury disagreed and sentenced him to 30 years in prison in February 2005.
In 2004, the U.S. Food and Drug Administration required that all antidepressants carry the agency's most serious "black box" warning, which cautions that the drugs can cause suicidal thoughts or abnormal behaviors in teenage users.

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