Drug Uses
Remeron Tablets are indicated for the treatment of major depressive disorder. Remeron is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.
How Taken
Remeron is available in a regular tablet formulation (Remeron) that should be swallowed with water.
The recommended starting dose for Remeron Tablets is 15 mg/day, administered in a single dose, preferably in the evening prior to sleep.
Warnings/Precautions
Do not take Remeron if you are currently taking, or have taken within the last 14 days, a monoamine oxidase inhibitor.
Before taking Remeron, tell your doctor if you have liver disease; have kidney disease; have a manic-depressive disorder; have blood problems; have high or low blood pressure or heart disease; have had a heart attack in the last 6 weeks; or have epilepsy or seizures.
You may not be able to take Remeron, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Remeron is in the FDA pregnancy category C. This means that it is not known whether Remeron will harm an unborn baby. Do not take Remeron without first talking to your doctor if you are pregnant.
It is not known whether Remeron passes into breast milk. Do not take Remeron without first talking to your doctor if you are breast-feeding a baby.
If you are over 60 years of age, you may be more likely to experience side effects such as drowsiness, dizziness, unsteadiness, feeling uncoordinated and low blood pressure. You may require a lower dose of this medication.
Missed Dose
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.
Possible Side Effects
If you experience any of the following serious side effects, stop taking Remeron and call your doctor immediately or seek emergency medical treatment: an allergic reaction (swelling of the lips, face, or tongue; difficulty breathing); seizures; a fast or irregular heartbeat; or fever, chills, a sore throat, flu-like symptoms, or sores in your mouth or nose.
Other, less serious side effects may be more likely to occur. Continue to take Remeron If you experience any of the following serious side effects, stop taking Remeron and call your doctor immediately or seek emergency medical treatment: drowsiness; nausea; increase in weight or appetite; dizziness; dry mouth; constipation; or mild tremor.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Storage
Store at controlled room temperature 20°- 25° C(68°- 77° F). Dispense in a tight, light resistant container.
Overdose
Signs and symptoms reported in association with overdose included disorientation, drowsiness, impaired memory, and tachycardia. There were no reports of ECG abnormalities, coma or convulsions following overdose with Remeron alone. Seek emergency medical attention.
More Information
Use caution when driving, operating machinery, or performing other hazardous activities. Remeron may cause drowsiness and dizziness. If you experience drowsiness or dizziness, avoid these activities.
Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
Avoid the use of alcohol while taking Remeron. Alcohol may increase drowsiness and dizziness.
Disclaimer
This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.
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FRIDAY, Oct. 12 (HealthDay News) -- Antidepressant drugs called selective serotonin reuptake inhibitors (SSRIs), which include Celexa, Paxil, Prozac and Zoloft, can double the risk of gastrointestinal bleeding, and the threat is more than six times higher if patients take aspirin and similar pain medications at the same time as SSRIs, a new study finds.
"Clinicians who prescribe these medications should be aware of the potential risk and may need to consider alternatives," senior researcher Dr. Sonal Singh, assistant professor of internal medicine at Wake Forest University School of Medicine, in Winston-Salem, N.C., said in a prepared statement.
His team published the findings in the journal Alimentary Pharmacology & Therapeutics.
In addition to depression, SSRIs are also used to treat panic disorder and obsessive-compulsive disorder. There's growing evidence that SSRIs may be associated with upper gastrointestinal (GI) bleeding.
Singh and colleagues analyzed data from four studies involving 153,000 patients. They found that those taking SSRIs were nearly twice as likely to develop upper GI bleeding as people who weren't taking the drugs.
When patients taking SSRIs also took nonsteroidal anti-inflammatory drugs (NSAIDs) -- such as aspirin, Aleve and Celebrex -- they were six times more likely to develop upper GI bleeding than people who weren't taking either type of drug.
The combined use of SSRIs and NSAIDs may have a "synergistic effect" that greatly increases the risk of upper GI bleeding beyond the risk posed by each kind of drug alone, the study authors suggested.
"While the risk to an individual may increase by only a small amount, the impact to the general population is likely to be substantial because of the large numbers of people who use these drugs," Singh said.
He and his colleagues estimated that one of every 411 patients over age 50 taking an SSRI, and one out of 82 taking both an SSRI and a NSAID, is likely to develop upper GI bleeding requiring hospitalization.
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