Drug Uses

Ultracet is a unique pain medication. It is used to relieve moderate, acute pain such as pain following surgical procedures, including dental surgery. Ultracet may be used for other types of pain as determined by your health care provider.

How Taken

Take Ultracet tablets orally. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If Ultracet upsets your stomach, take it with food or milk. Do not take more than 2 tablets at a time or more than 8 tablets per day. Higher doses may cause severe side effects, do not take more medication than your prescriber has instructed.

Warnings/Precautions

DO NOT TAKE Ultracet IF YOU HAVE HAD SEVERE ALLERGIC REACTION to codeine. A severe allergic reaction includes a severe rash, hives, breathing difficulties, or dizziness. IF YOU EXPERIENCE difficulty breathing, tightness of chest, swelling of eyelids, face or lips or if you develop a rash or hives, tell your doctor immediately. Do not take any more doses of Ultracet unless your doctor tells you to do so. DO NOT EXCEED THE RECOMMENDED DOSE or take Ultracet for longer than prescribed. Ultracet MAY BE HABIT FORMING. Use caution driving or operating machinery. DO NOT DRINK ALCOHOL while taking Ultracet. DO NOT TAKE other products containing acetaminophen (check labels closely) while you are taking Ultracet. IF DIZZINESS OCCURS, sit or stand up slowly. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor that you are taking Ultracet. IF YOU EXPERIENCE WITHDRAWAL SYMPTOMS (nervousness, sweating, nausea, diarrhea, tremor, trouble sleeping), check with your doctor. Discuss with your doctor is you are planning on getting pregnant. Ultracet IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking Ultracet.

Missed Dose

If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Possible Side Effects

Side effects that you should report to your prescriber or health care professional as soon as possible:
Rare or uncommon: changes in vision; difficulty breathing, shortness of breath; fast or irregular heartbeat; hallucinations (seeing and hearing things that are not really there); not passing urine as often as usual; redness, blistering, peeling or loosening of the skin, including inside the mouth; skin rash, itching; seizures (convulsions); yellow tint to your skin or whites of your eyes.
More common: anxiety, agitation; vomiting.
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome); constipation or diarrhea; difficulty sleeping; dizziness, drowsiness; dry mouth; false sense of well being, feeling of unreality, mood changes; headache; indigestion; itching; nausea; sweating or flushing.

Storage

Keep out of reach of children in a container that small children cannot open. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Overdose

Seek emergency medical attention. Symptoms of a Ultracet overdose include nausea; vomiting; sweating; difficulty breathing; shallow, weak breathing; and seizures.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Ultracet may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Do not take other prescription or over-the-counter medicines that contain acetaminophen (Tylenol, pain relievers, cold and flu medicines, others) during treatment with Ultracet. Taking too much acetaminophen may be harmful. Avoid sleeping pills, tranquilizers, sedatives and antihistamines except under the supervision of your doctor. Ultracet may cause drowsiness and these agents may worsen this effect.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The nutritional supplement glucosamine boosts the pain relieving power of ibuprofen, according to a new study by Temple University researchers in the Journal of Pharmacology and Experimental Therapeutics (JPET). This new drug combination could one day allow patients to take a lower dose and get the same pain relief with fewer unwanted side effects.
Ronald Tallarida, Ph.D., and Alan Cowan, Ph.D., of Temple's School of Medicine, and Robert Raffa, Ph.D., of Temple's School of Pharmacy, conducted the study "Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice," which was published in the November 2003 issue of JPET.
Ibuprofen is a non-steroidal anti-inflammatory drug, or NSAID. NSAIDs, which also include aspirin, are quite effective in relieving pain. They are so effective, in fact, that pain sufferers sometimes take higher and higher doses in hope of more pain relief. High doses of NSAIDs, especially when taken over long periods of time, can cause gastrointestinal upset, such as heartburn, or even bleeding.
"Combining pain relievers into one pill can increase patient compliance, simplify prescribing, and improve efficacy without increasing side effects, or conversely, decrease side effects without losing efficacy," said Raffa.
In addition to these benefits, drug combinations can also sometimes yield a totally unexpected effect, such as the magnification of a drug's powers. "When this happens, a phenomenon known as drug synergism, it's like finding buried treasure," added Tallarida.
Glucosamine, a naturally occurring substance in the body, which is also available in synthetic form over the counter, is used to treat osteoarthritis, a painful, degenerative joint disorder. While it has been shown to prevent and repair bone and cartilage damage, researchers have yet to demonstrate that glucosamine actually blocks pain.
"We embarked on this study with several questions: Can glucosamine actually block pain? And, can glucosamine improve the pain-relieving powers of other drugs when the two are combined?" said Tallarida.
First, the researchers confirmed that glucosamine, alone, does not block pain. It's believed that any pain-relieving properties of glucosamine are a side effect of its ability to repair bone damage. Next, they combined glucosamine with a variety of NSAIDs at a variety of dosages. With several NSAIDs, including naproxen, the addition of glucosamine caused an additive effect, meaning the sum of each drug's properties. When combined with aspirin or acetaminophen, the result was subadditive, or less than the sum of each drug's properties. But when combined with ibuprofen, the researchers found pain relief was enhanced and therefore synergistic.
"The next step will be to study this drug combination in clinical trials to see whether it can enhance pain relief or offer pain relief using a lower dose of ibuprofen and therefore a lower risk of side effects," said Cowan.
The researchers are also investigating other possible drug combinations for the potential relief of pain. Raffa and Tallarida played a role in the development of Ultracet, a combination of tramadol and acetominophen used in the treatment of pain. And Cowan contributed to the development of buprenorphine which, when combined with naloxone, is used in the treatment of opiate addiction.

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