Drug Uses

Wellbutrin SR (Anti Depressant) is a pharmaceutical prescription antidepressant, which acts directly on the brain and other nerve cells. It is also used to treat ADHD (Attention Deficit Disorder), bipolar depression, chronic fatigue syndrome, cocaine addiction, nicotine addiction, and lower back pain. Also, aids in quitting smoking (identical to Zyban). It is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents.

How Taken

Wellbutrin SR comes as a tablet to take it orally. It is usually taken one to three times a day and may be taken with or without food. Do not crush, chew, or divide Wellbutrin SR. Do not stop taking Wellbutrin SR without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Warnings/Precautions

Before taking Wellbutrin SR, tell your doctor if you have: history of seizures or head injury or brain tumor, heart disease, liver or kidney disease, eating disorder, diabetes, alcohol dependence, any allergies, the intent to quit smoking. Because of the possibility this drug will make you dizzy and affect coordination, do not drive or operate machinery until you get used to the drug's effects. Limit or avoid consumption of alcoholic beverages; alcohol can increase your risk of seizures. Chronic alcohol users who suddenly stop the intake of alcohol while taking Wellbutrin SR may increase the risk of having seizures. Suddenly stopping certain tranquilizers is not recommended because doing so may increase the risk of having seizures. If you are over 65 years old you may be more sensitive to the effects of this drug. Tell your doctor if you are pregnant or plan to become pregnant before taking this drug. This drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Missed Dose

Take any missed dose as soon as possible but not if it is within 4 hours of the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose.

Possible Side Effects

This medication is generally well tolerated. Dry mouth, headache, increased sweating, nausea/vomiting, constipation, anxiety, fatigue and blurred vision may occur. If these effects persist or worsen, notify your doctor. Report promptly: unusual weight loss or gain, palpitations, agitation, trouble sleeping. Unlikely but report promptly: tremor, dizziness, fainting, mood changes, slowed movements, difficulty urinating, decreased sex drive, and drowsiness. Very unlikely but report promptly: seizures, mental problems, fever, muscle aches, yellowing of the eyes or skin. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms may include trouble breathing, rash, itching, swelling, or severe dizziness. If you notice other effects not listed above, contact your doctor or pharmacist.

Storage

Store at controlled room temperature, 20° to 25°C (68° to 77°F). Dispense in a tight, light-resistant container.

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of a Wellbutrin SR overdose include seizures, hallucinations, loss of consciousness, weakness, a fast heartbeat, and heart attack.

More Information

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. Too much of this medicine can increase the risk of a seizure. Limit the consumption of caffeine while taking Wellbutrin SR.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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A team of researchers from the University of Texas at Austin, led by Kereshmeh Taravosh-Lahn, conducted an animal study in juvenile and adult golden hamsters. The researchers split the hamsters into three groups: adult hamsters receiving either high or low doses of fluoxetine (Prozac), adolescent hamsters receiving high or low doses of fluoxetine, and hamsters receiving placebo. A high dose consisted of 20 mg per kilo of body weight, while a low dose was 10 mg per kilo.
After administering the drugs, the researchers placed a smaller, same-sex hamster into the cage of each experimental animal, and filmed any fights or displays of aggressive behavior. The researchers found that the adolescent hamsters on a low dose of Prozac were far more aggressive than those on high doses of the drug.
The high-dose hamsters initiated 65 percent fewer attacks than the placebo group, while the low-dose hamsters initiated 40 percent more fights. Adult hamsters on both high and low doses of Prozac initiated fewer fights than the placebo group, the researchers found.
Taravosh-Lahn said the difference in aggression between the high- and low-dose hamsters could be because fluoxetine binds serotonin -- a mood-altering brain chemical -- to different receptors in the brain, depending on the dose. The researchers speculate that low doses of the drug may bind to aggression-inducing receptors, while higher doses more readily bind to aggression-inhibiting receptors. Mature animals also have fewer aggression-inducing inhibitors for the drugs to bind to, compared to adolescent animals.
"We underestimate the difference between the juvenile brain and the adult brain," said Taravosh-Lahn. "It seems there needs to be more research on the effects of antidepressants on kids."
Earlier studies have linked use of antidepressant drugs -- specifically SSRIs (selective serotonin reuptake inhibitors) -- to violent and aggressive behavior in children. A high-profile case involving Pzifer's Zoloft SSRI is that of Christopher Pittman, who at the age of 12 shot and killed his grandparents, then set their house on fire. Pittman's attorneys argued that the Zoloft he was taking at the time of the killings caused him to become violent, but a jury disagreed and sentenced him to 30 years in prison in February 2005.
In 2004, the U.S. Food and Drug Administration required that all antidepressants carry the agency's most serious "black box" warning, which cautions that the drugs can cause suicidal thoughts or abnormal behaviors in teenage users.

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