Drug Uses

Zithromax is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, skin infections, ear infections, and sexually transmitted diseases.

How Taken

Zithromax comes as a capsule, tablet, and liquid to take it orally. It is usually taken once a day for 2-5 days. Take Zithromax exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well before each use to mix the medication evenly. The capsules and tablets should be taken with a full glass of water. Continue to take Zithromax even if you feel well. Do not stop taking Zithromax without talking to your doctor. Take Zithromax liquid at least 1 hour before or 2 hours after meals. The capsule and tablet may be taken with or without food. If it upsets your stomach, take it with food.

Warnings/Precautions

Before taking Zithromax, tell your doctor if you have liver disease. You may not be able to take Zithromax, or you may require a lower dose or special monitoring during treatment. Zithromax is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Zithromax passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Zithromax and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue). Other, less serious side effects may be more likely to occur. Continue to take Zithromax and talk to your doctor if you experience nausea, vomiting, diarrhea, or abdominal pain; unusual dizziness, fatigue, or headache; vaginal yeast infection; a rash; or increased sensitivity to sunlight. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Zithromax tablets should be stored between 15° to 30° C (59° to 86°F). Store constituted suspension between 5° to 30°C (41° to 86°F) and discard when full dosing is completed or within 10 days. Shake well before each use. Oversized bottle provides shake space. Keep tightly closed.

Overdose

Seek emergency medical attention. Symptoms of Zithromax overdose include nausea, vomiting, diarrhea, and abdominal discomfort.

More Information

Avoid prolonged exposure to sunlight. Zithromax may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The Problem of Antimicrobial Resistance Overview Since antibiotics and other antimicrobial drugs first became widely used in the World War II era, they have saved countless lives and blunted serious complications of many feared diseases and infections. The success of antimicrobials against disease-causing microbes is among modern medicine's great achievements. After more than 50 years of widespread use, however, many antimicrobials are not as effective as they used to be. Over time, some bacteria have developed ways to circumvent the effects of antibiotics. Widespread use of antibiotics is thought to have spurred evolutionarily adaptations that enable bacteria to survive these powerful drugs. Other microbes such as viruses, fungi, and parasites have developed resistance as well. Antimicrobial resistance provides a survival benefit to microbes and makes it harder to eliminate infections from the body. Ultimately, the increasing difficulty in fighting off microbes leads to an increased risk of acquiring infections in a hospital or other setting. Diseases such as tuberculosis, gonorrhea, malaria, and childhood ear infections are now more difficult to treat than they were just a few decades ago. Drug resistance is an especially difficult problem for hospitals harboring critically ill patients who are less able to fight off infections without the help of antibiotics. Heavy use of antibiotics in these patients selects for changes in bacteria that bring about drug resistance. Unfortunately, this worsens the problem by producing bacteria with greater ability to survive even in the presence of our strongest antibiotics. These even stronger drug-resistant bacteria continue to prey on vulnerable hospital patients. To help curb this problem, the Centers for Disease Control and Prevention (CDC) provides hospitals with prevention strategies and educational materials to reduce antibiotic resistance in health care settings. According to CDC statistics Nearly 2 million patients in the United States get an infection in the hospital each year About 90,000 of those patients die each year as a result of their infection, up from 13,300 patient deaths in 1992 More than 70 percent of the bacteria that cause hospital-acquired infections are resistant to at least one of the antibiotics most commonly used to treat them People infected with antibiotic-resistant organisms are more likely to have longer hospital stays and require treatment with second- or third-choice medicines that may be less effective, more toxic, and more expensive In short, antimicrobial resistance is driving up health care costs, increasing the severity of disease, and increasing the death rates from certain infections. ENVIRONMENT FORCES EVOLUTIONARY CHANGE A key factor in the development of antibiotic resistance is the ability of infectious organisms to adapt quickly to new environmental conditions. Bacteria are single-celled organisms that, compared with higher life forms, have small numbers of genes. Therefore, even a single random genetic mutation can greatly affect their ability to cause disease. And because most microbes reproduce by dividing every few hours, bacteria can evolve rapidly. A mutation that helps a microbe survive exposure to an antibiotic will quickly become dominant throughout the microbial population. Microbes also often acquire genes from each other, including genes that confer resistance. The advantage microbes gain from their innate adaptability is augmented by the widespread and sometimes inappropriate use of antibiotics. A physician, wishing to placate an insistent patient who has a virus or an as-yet undiagnosed condition, sometimes inappropriately prescribes antibiotics. Also, when a patient does not finish taking a prescription for antibiotics, some bacteria may remain. These bacterial survivors are more likely to develop resistance and spread. Hospitals also provide a fertile environment for antibiotic-resistant germs as close contact among sick patients and extensive use of antibiotics select for resistant bacteria. Scientists also believe that the practice of adding antibiotics to agricultural feed promotes drug resistance.

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